In the search for therapeutic substances with improved properties, an important and promising method is the synthesis of cocrystals and salts based on known pharmaceuticals.

In the new publication Structural and theoretical studies of amantadinium fenamates in the journal Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials an employee of our institute, dr Monika Krawczyk, in collaboration with employees of the Faculty of Pharmacy of the Medical University in Wrocław, describes newly obtained amantadine salt crystals with phenamic acids, along with structural and theoretical studies of said bonds.

Amantadine is used in treatment of the Parkinson’s disease symptoms, while phenamic acids belong to the group of nonsteroidal anti-inflammatory drugs (NSAID).

In this work, X-ray, thermal, IR spectroscopic studies and theoretical calculations by QTAIM (Quantum Theory of Atoms in Molecules) and NCI (Noncovalent Interaction) methods were performed. X-ray structural studies and theoretical analysis of the crystals revealed the presence of characteristic motifs of 10-member rings in them, formed by hydrogen bonds and networks of weak interactions.